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Multiple recurrent giant cell lesions associated with high circulating levels of parathyroid hormone-related peptide in a young adult

Authors
Journal
British Journal of Oral and Maxillofacial Surgery
0266-4356
Publisher
Elsevier
Publication Date
Volume
29
Issue
2
Identifiers
DOI: 10.1016/0266-4356(91)90092-j
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Parathyroid hormone-related peptide (PTHrP, PLY) has previously been identified and assays are now available which can be used in clinical situations. A case is reported of a normocalcaemic young adult female in whom multifocal recurrent giant cell osteolytic lesions in the maxilla and elsewhere were associated with a raised plasma level of parathyroid hormone-related peptide. The lesions were histologically identical to reparative giant cell granuloma of the jaws and to osteitis fibrosa cystica associated with hyperparathyroidism.

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