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Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus.

Authors
Type
Published Article
Journal
Alcoholism, clinical and experimental research
Publication Date
Volume
26
Issue
10
Pages
1468–1478
Identifiers
PMID: 12394279
Source
Medline
License
Unknown

Abstract

The results support the contention that acamprosate, like ifenprodil, interacts with polyamines and that these compounds may be effective in reducing consequences of ethanol withdrawal. NMDAR activation is also strongly implicated in ethanol withdrawal neurotoxicity, but whether acamprosate causes any of these effects in this preparation directly via the NMDAR remains uncertain.

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