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Beta-blockers in the environment: Part I. Mobility and hydrolysis study

Authors
Journal
The Science of The Total Environment
0048-9697
Publisher
Elsevier
Publication Date
Volume
493
Identifiers
DOI: 10.1016/j.scitotenv.2014.06.023
Keywords
  • Sorption
  • Soil
  • Hydrolytic Stability
Disciplines
  • Ecology
  • Geography
  • Pharmacology

Abstract

Abstract Beta-blockers (BB) are one of the most widely used pharmaceuticals whose presence in different environmental compartments has already been proven in concentrations of even up to a few μgL−1. However, our knowledge of their fate in the environment is still scarce. To obtain a better understanding on the environmental behavior of three selected BB comprehensive laboratory experiments assessing their mobility and hydrolytic stability has been conducted. Propranolol, metoprolol and nadolol – the most commonly consumed and detected in environmental samples – were selected as representatives of this group of pharmaceuticals. The objectives of our research were: (i) evaluation of the sorption potential and an explanation of the sorption mechanisms of these compounds onto soil and clay mineral (kaolinite); and (ii) investigation of the hydrolytic stability of these BB according to OECD 111. This comprehensive study supports the Environmental Risk Assessment of these pharmaceuticals.

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