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Evaluation of prenatal diagnosis of isolated ventriculomegaly

Cerebrospinal Fluid Research
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/1743-8454-7-s1-s11
  • Oral Presentation
  • Medicine


Evaluation of prenatal diagnosis of isolated ventriculomegaly ORAL PRESENTATION Open Access Evaluation of prenatal diagnosis of isolated ventriculomegaly Mami Yamasaki1*, Masahiro Nonaka1, Yohei Bamba1, Chika Teramoto2, Rituko Pooh3 From 54th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Vancouver, Canada. 7-10 July 2010 Background The prenatal management of hydrocephalus with myelo- meningcele(MMC) has been established in recent years. However, other types of fetal hydrocephalus so called isolated ventriculomegaly show wide heterogeneity in prognosis, as various diseases are included. For the proper counselling .it is very important to clarify this entity. Materials and methods Our objective is to evaluate how to estimate the appro- priate clinical outcome prenatally in isolated ventriculo- megaly. Method Retrospective study, single institute (Osaka National Hospital) Materials One hundred and seventeen cases with fetal hydrocephalus were treated at Osaka National Hospital from 1992 to 2010. As 35 cases with MMC and fetal brain tumor are excluded, 82 cases were selected for this study. Results Final diagnosis was as still isolated ventriculomegaly in 30 cases. Other anomaly are detected in 19cases (X-linked hydrocephalus in5, atresia of Monro in 2, cor- pus callosum agenesis in 3, lissencephaly in 2, other type of hereditaly hydrocephalus in 2, chromosomal anomaly in 4 and a EEC syndrome). Final diagnosis were categorized in secondary hydrocephalus in 9 cases (virus infection in 2 and fetal intracranial hemorrhage in7) and 24 cases are diagnosed as other type of malfor- mation( holoprosencephaly in 4 ,Dandy Walker syn- drome in 3 cases, Jobert syndrome in a case, arachnoid cyst in 9 cases and encephalocele in 7cases). With exclu- sion of 6 aborted cases and fourteen unknown cases due to too young to evaluate or lost of follow-up, final out- come are analyzed in 62 cases. Of 62cases, 11% was dead in utero or after birth, 26% showed severe re

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