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Serum tetraiodothyroacetate (T4A) levels in normal healthy euthyroid individuals determined by gas chromatography-mass fragmentography (GC-MF)

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
94
Issue
3
Identifiers
DOI: 10.1016/0009-8981(79)90074-3

Abstract

Abstract A gas chromatography-mass fragmentography (GC-MF) assay for T 4A in human serum is described. The assay involves a multistage extraction, followed by conversion of T 4A to its dimethyl derivative prior to GC-MF. Using this assay, the concentration of T 4A in 37 normal euthyroid subjects was, mean ± S.D., 114.5 ± 26.4 pmol/l, which is considerably lower than previous reports. Thyroxine binding prealbumin (TBPA) did not appear to be a major determinant of T 4A concentration.

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