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Accelerated and navigator-gated look-locker imaging for cardiac T1 Estimation (ANGIE) with reduced motion artifact

Authors
Journal
Journal of Cardiovascular Magnetic Resonance
1097-6647
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
14
Identifiers
DOI: 10.1186/1532-429x-14-s1-o110
Keywords
  • Oral Presentation
Disciplines
  • Medicine

Abstract

Accelerated and navigator-gated look-locker imaging for cardiac T1 Estimation (ANGIE) with reduced motion artifact ORAL PRESENTATION Open Access Accelerated and navigator-gated look-locker imaging for cardiac T1 Estimation (ANGIE) with reduced motion artifact Bhairav B Mehta1*, Xiao Chen1, Michael Salerno3,2, Christopher M Kramer3,2, Frederick H Epstein1,2 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Background T1 mapping of the left ventricle is routinely performed using Modified Look-Locker Inversion Recovery (MOLLI) [1] in a variety of disease settings [2]. MOLLI requires relatively long breathholds, and consequently sequences of MOLLI images may be misregistered due to respiratory drift. We sought to develop a T1 mapping sequence that would not require breathholding and would not have misregistration problems. We used k- space segmentation and navigator gating to eliminate respiratory artifact, and compressed sensing [3] (CS) to accelerate image acquisition. CS utilizes undersampling in k-t space along with nonlinear iterative image recon- struction. CS is well-suited to Look-Locker imaging because these images, which vary smoothly from one inversion time to the next, exhibit time-domain sparsity. Methods Imaging was performed on a 1.5T scanner (Avanto, Sie- mens, Germany). The proposed sequence, Accelerated and Navigator-Gated look-locker Imaging for cardiac T1 Estimation (ANGIE), was compared to a standard MOLLI sequence in 6 healthy volunteers (age 25±2 yrs). ANGIE used inversion-recovery Look-Locker imaging where image acquisition was segmented and accepted or rejected based on navigator gating. Each inversion was followed by 4 consecutive R-R intervals in which seg- mented data were acquired and 2 R-R intervals for unperturbed T1 relaxation. This inversion and acquisi- tion pattern was repeated until sufficient data for CS reconstruction were acquired. The CS acceleration rate was approximately 2.3. For each frame, we acquired 18 cent

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