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Maximum Tolerated Dose

Authors
Publisher
Elsevier Inc.
Identifiers
DOI: 10.1016/b978-0-12-386454-3.00874-5
Keywords
  • Dose Range–Finding Study
  • Redbook

Abstract

Abstract The maximum tolerated dose (MTD) is commonly estimated to be the maximum dose that can be administered for the duration of a specific study that will not compromise the survival of the animals by causes other than carcinogenicity. If the MTD has been chosen appropriately, there should be no adverse effect on survival, only a modest decrement in body weight gain and minimal overt signs of toxicity. The MTD has been exceeded if there is increased mortality, severe body weight decrement, or marked signs of toxicity. It should be noted that another meaning for MTD has sometimes been ‘minimum toxic dose.’

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