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Absorbed doses to patients from 191Pt-, 193mPt- and 195mPt-cisplatin.

Authors
Type
Published Article
Journal
Applied Radiation and Isotopes
0969-8043
Publisher
Elsevier
Publication Date
Volume
51
Issue
5
Pages
581–586
Identifiers
PMID: 10464923
Source
Medline
License
Unknown

Abstract

Cisplatin, a chemotherapeutic drug, can be synthesized using radioactive platinum and then used for pharmacokinetic studies and tumor imaging. We have calculated the absorbed doses to various organs and tissues as well as the effective doses from 191Pt-, 193mPt- and 195mPt-cisplatin after administration to humans for diagnostic purposes. Liver was the organ that received the highest absorbed dose. The effective dose from 191Pt-, 193mPt- and 195mPt-cisplatin was 0.10 +/- 0.02, 0.17 +/- 0.04 and 0.23 +/- 0.05 mSv/MBq respectively.

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