Affordable Access

Absolute linkage of celiac disease and dermatitis herpetiformis to HLA-DQ.

Authors
  • Balas, A
  • Vicario, J L
  • Zambrano, A
  • Acuña, D
  • García-Novo, D
Type
Published Article
Journal
Tissue antigens
Publication Date
Jul 01, 1997
Volume
50
Issue
1
Pages
52–56
Identifiers
PMID: 9243756
Source
Medline
License
Unknown

Abstract

This report shows the absolute genetic linkage of celiac disease (CD) to the HLA-DQ region, and supports the fact that dermatitis herpetiformis (DH) follows the same pattern of HLA-mediated susceptibility in extensive series of Caucasian Spanish patients. Ninety-five percent of CD (201 of 212) and 100% of DH (55) patients could produce DQ alpha 1*0501-DQ beta 1*02 heterodimers. Negative CD patients for this combination were mostly DR4-DQ8 (DQA1*03-DQB1*0302) (9 OF 11), along with a restricted number of complementary chromosomes. Comparison of observed and expected DQA1-DQB1 genotype distributions (Hardy-Weinberg equilibrium) showed that the excess of patients with DQB1*02 in double doses would be the consequence for which this allele should be complemented by DQA1*0501. Homozygosity for DQA1*0501 would restrain susceptibility to CD and DH.

Report this publication

Statistics

Seen <100 times