Affordable Access

Absolute bioavailability of nicotine applied to different nasal regions.

Authors
  • Johansson, C J
  • Olsson, P
  • Bende, M
  • Carlsson, T
  • Gunnarsson, P O
Type
Published Article
Journal
European journal of clinical pharmacology
Publication Date
Jan 01, 1991
Volume
41
Issue
6
Pages
585–588
Identifiers
PMID: 1815971
Source
Medline
License
Unknown

Abstract

The absolute bioavailability of nicotine administered nasally, as drops to the nasal conchae and nasal septum, and as a nasal spray, has been studied in eight healthy volunteers. Single nasal doses of 1 mg nicotine were given and plasma concentrations of nicotine were followed for 6 h. Compared to an intravenous infusion of nicotine, the bioavailability of the nasal administrations was 60 to 75%. The rate of absorption was fast, the maximum concentration being reached after about 10 min. In the present study, there was no significant difference in the rate or extent of absorption between the different nasal treatments.

Report this publication

Statistics

Seen <100 times