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Absence of a significant renal threshold for two aromatic acids in phenylketonuric children over two years of age.

Authors
  • Langenbeck, U
  • Behbehani, A
  • Mench-Hoinowski, A
  • Petersen, M
Type
Published Article
Journal
European journal of pediatrics
Publication Date
Aug 01, 1980
Volume
134
Issue
2
Pages
115–118
Identifiers
PMID: 7439195
Source
Medline
License
Unknown

Abstract

There is a steady and nonlinear relationship between the levels of both phenylpyruvic acid (PPA) and o-hydroxyphenylacetic acid (oOPAA) in urine and the plasma levels of phenylalanine (phe) in children more than two years of age with phenylketonuria (PKU). If phe levels in blood rise above 0.35 mM (5.8 mg/100 ml) both aromatic acids are found regularly in urine. Typically, urinary concentrations of PPA are about 5 times higher than those of oOPAA. This report is based on the analysis of 94 samples from 51 children, on or off diet.

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