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ABSENCE SEIZURES | Thalamic Neurons and Networks Related to Absence Epilepsy

Authors
  • Budde, T.
  • Pape, H.-C.
Type
Book
Journal
Encyclopedia of Basic Epilepsy Research
Publication Date
Jan 01, 2009
Pages
22–28
Identifiers
DOI: 10.1016/B978-012373961-2.00142-9
ISBN: 978-0-12-373961-2
Source
Elsevier
Keywords
License
Unknown

Abstract

Childhood absence epilepsy is characterized by sudden onset and offset episodes of bilaterally generalized spike-and-wave discharges (SWDs) in the thalamocortical system, associated with loss of consciousness. Studies of genetic rat models of absence epilepsy indicate that SWDs have a cortical initiation site and can develop from naturally occurring rhythms in the thalamocortical system. In both thalamus and neocortex, genetically determined, absence-related SWDs are the consequence of pathological hyper-synchronized, rhythmic excitations and inhibitions that result (in comparison to epilepsy free animals) from alterations in intrinsic neuronal, synaptic, and network mechanisms in epileptic individuals.

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