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Absence of the dermatan sulfate chain of decorin does not affect mouse development

Authors
  • Moffatt, Pierre1, 2
  • Geng, Yeqing1
  • Lamplugh, Lisa1
  • Nanci, Antonio3
  • Roughley, Peter J.1, 2
  • 1 Shriners Hospitals for Children – Canada, Research Center, 1003 Boulevard Décarie, Montréal, QC, H4A 0A9, Canada , Montréal (Canada)
  • 2 Faculty of Medicine, McGill University, Department of Human Genetics, Montreal, QC, Canada , Montreal (Canada)
  • 3 Faculty of Dentistry, Université de Montréal, Laboratory for the Study of Calcified Tissues and Biomaterials, Department of Stomatology, Montréal, QC, Canada , Montréal (Canada)
Type
Published Article
Journal
Journal of Negative Results in BioMedicine
Publisher
BioMed Central
Publication Date
Apr 17, 2017
Volume
16
Issue
1
Identifiers
DOI: 10.1186/s12952-017-0074-3
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundIn vitro studies suggest that the multiple functions of decorin are related to both its core protein and its dermatan sulfate chain. To determine the contribution of the dermatan sulfate chain to the functional properties of decorin in vivo, a mutant mouse whose decorin lacked a dermatan sulfate chain was generated.ResultsHomozygous mice expressing only the decorin core protein developed and grew in a similar manner to wild type mice. In both embryonic and postnatal mice, all connective tissues studied, including cartilage, skin and cornea, appeared to be normal upon histological examination, and their collagen fibrils were of normal diameter and organization. In addition, abdominal skin wounds healed in an identical manner in the mutant and wild type mice.ConclusionsThe absence of a dermatan sulfate chain on decorin does not appear to overtly influence its functional properties in vivo.

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