Affordable Access

deepdyve-link
Publisher Website

Stay Home! Stay Safe! First Post-Discharge Cardiologic Evaluation of Low-Risk-Low-BNP Heart Failure Patients in COVID-19 Era.

Authors
  • Aspromonte, Nadia1, 2
  • Cappannoli, Luigi2
  • Scicchitano, Pietro3
  • Massari, Francesco3
  • Pantano, Ivan4
  • Massetti, Massimo1, 2
  • Crea, Filippo1, 2
  • Valle, Roberto4
  • 1 Department of Cardiovascular Sciences, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy. , (Italy)
  • 2 Institute of Cardiology, Catholic University of the Sacred Heart, 00168 Rome, Italy. , (Italy)
  • 3 Cardiology Section, F. Perinei Hospital, 70022 Altamura (BA), Italy. , (Italy)
  • 4 Cardiology Department, Madonna della Navicella Hospital, 30015 Chioggia (VE), Italy. , (Italy)
Type
Published Article
Journal
Journal of Clinical Medicine
Publisher
MDPI AG
Publication Date
May 14, 2021
Volume
10
Issue
10
Identifiers
DOI: 10.3390/jcm10102126
PMID: 34069041
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The COVID-19 pandemic has had a deep impact on periodic outpatient evaluations. The aim of this study was to evaluate the impact of low brain natriuretic peptide (BNP) values in predicting adverse events in heart failure (HF) patients in order to evaluate implications for safe delay of outpatient visits. This was a retrospective study. One-thousand patients (mean age: 72 ± 10 years, 561 women) with HF and BNP values <250 pg/mL at discharge were included. A 6-month follow-up was performed. The primary endpoint was a combination of deaths and readmissions for HF within 6-month after discharge. At 6-month follow-up, 104 events (10.4%) were recorded (65 HF readmissions and 39 all-cause deaths). Univariate Cox analysis identified as significant predictors of outcome were age (p < 0.001, hazard ratio [HR] = 1.044), creatinine (p = 0.001, HR = 1.411), and BNP (p < 0.001, HR = 1.010). Multivariate Cox regression confirmed that BNP (p < 0.001, HR = 1.009), creatinine (p = 0.016, HR = 1.247), and age (p = 0.013, HR = 1.027) were independent predictors of events in HF patients with BNP values <250 pg/mL at discharge. Patients with BNP values >100 pg/mL and creatinine >1.0 mg/dL showed increased events rates (from 4.3% to 19.0%) as compared to those with lower values (p < 0.000, HR = 4.014). Low pre-discharge BNP levels were associated with low rates of cardiovascular events in HF patients, independently of the frequency of follow-up.

Report this publication

Statistics

Seen <100 times