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ABROGATION OF ALLOGENEIC INHIBITION BY CORTISONE.

Authors
  • HELLSTROEM, K E
  • HELLSTROEM, I
  • HAUGHTON, G
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Jul 02, 1965
Volume
149
Issue
3679
Pages
82–84
Identifiers
PMID: 14300525
Source
Medline
Keywords
License
Unknown

Abstract

Tumor cells from homozygous mice grow better upon transplanation to syngeneic mice than to F(1) hybrids between the tumor strain and a foreign strain. The inhibition of cell growth in the hybrids (called allogeneic inhibition), which is detected by tumor transplantation into mice, cotuld be abrogated by treatment of the recipient mice with cortisone acetate. Cortisone also abolished allogeneic inhibition in vitro; abolition was detected by treating tumor cultures with cell extracts containing foreign isoantigens of the H-2 type.

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