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Abnormalities of quantities and functions of linker for activations of T cells in severe aplastic anemia.

Authors
  • Sheng, Weiwei
  • Liu, Chunyan
  • Fu, Rong
  • Wang, Huaquan
  • Qu, Wen
  • Ruan, Erbao
  • Wang, Guojin
  • Liu, Hong
  • Wu, Yuhong
  • Song, Jia
  • Xing, Limin
  • Guan, Jing
  • Li, Lijuan
  • Liu, Hui
  • Shao, Zonghong
Type
Published Article
Journal
European Journal Of Haematology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2014
Volume
93
Issue
3
Pages
214–223
Identifiers
DOI: 10.1111/ejh.12327
PMID: 24673455
Source
Medline
Keywords
License
Unknown

Abstract

Our findings demonstrate that dysregulation of LAT expression and activation may contribute to over-function of T cells, imbalance of Th1/Th2 subsets and thus lead to hematopoiesis failure in SAA. Immunosuppressive therapy dramatically reduced the expression of LAT making it an attractive therapeutic target in SAA.

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