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Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota.

Authors
  • Bishehsari, Faraz1
  • Engen, Phillip A2
  • Adnan, Darbaz2
  • Sarrafi, Shahram2
  • Wilber, Sherry2
  • Shaikh, Maliha2
  • Green, Stefan J3
  • Naqib, Ankur2
  • Giron, Leila B4
  • Abdel-Mohsen, Mohamed4
  • Keshavarzian, Ali5
  • 1 Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois. Electronic address: [email protected]
  • 2 Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois.
  • 3 Genome Research Core, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois.
  • 4 The Wistar Institute, Philadelphia, Pennsylvania.
  • 5 Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois; Department of Physiology, Rush University Medical Center, Chicago, Illinois; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands. , (Netherlands)
Type
Published Article
Journal
Translational research : the journal of laboratory and clinical medicine
Publication Date
May 01, 2021
Volume
231
Pages
113–123
Identifiers
DOI: 10.1016/j.trsl.2020.11.007
PMID: 33221482
Source
Medline
Language
English
License
Unknown

Abstract

Obesity has become a common rising health care problem, especially in "modern" societies. Obesity is considered a low-grade systemic inflammation, partly linked to leaky gut. Circadian rhythm disruption, a common habit in modern life, has been reported to cause gut barrier impairment. Abnormal time of eating, defined by eating close to or during rest time, is shown to cause circadian rhythm disruption. Here, using a non-obesogenic diet, we found that abnormal feeding time facilitated weight gain and induced metabolic dysregulation in mice. The effect of abnormal time of eating was associated with increased gut permeability, estimated by sucralose and/or lactulose ratio and disrupted intestinal barrier marker. Analysis of gut microbiota and their metabolites, as important regulators of barrier homeostasis, revealed that abnormal food timing reduced relative abundance of butyrate-producing bacteria, and the colonic butyrate level. Overall, our data supported that dysbiosis was characterized by increased intestinal permeability and decreased beneficial barrier butyrate-producing bacteria and/or metabolite to mechanistically link the time of eating to obesity. This data provides basis for noninvasive microbial-targeted interventions to improve intestinal barrier function as new opportunities for combating circadian rhythm disruption induced metabolic dysfunction. Copyright © 2020 Elsevier Inc. All rights reserved.

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