Affordable Access

deepdyve-link
Publisher Website

Abiotic stress induced miRNA-TF-gene regulatory network: A structural perspective.

Authors
  • Sharma, Rinku1
  • Upadhyay, Shashankaditya2
  • Bhat, Basharat1
  • Singh, Garima1
  • Bhattacharya, Sudeepto3
  • Singh, Ashutosh4
  • 1 Department of life Sciences, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh 201314, India. , (India)
  • 2 Department of Mathematics, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh 201314, India. , (India)
  • 3 Department of Mathematics, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh 201314, India. Electronic address: [email protected] , (India)
  • 4 Department of life Sciences, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh 201314, India. Electronic address: [email protected] , (India)
Type
Published Article
Journal
Genomics
Publisher
Elsevier
Publication Date
Jan 01, 2020
Volume
112
Issue
1
Pages
412–422
Identifiers
DOI: 10.1016/j.ygeno.2019.03.004
PMID: 30876925
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

MicroRNAs (miRNAs) and transcription factors (TFs) are the largest families of trans-acting gene regulatory species, which are pivotal players in a complex regulatory network. Recently, extensive research on miRNAs and TFs in agriculture has identified these trans-acting regulatory species, as an effective tool for engineering new crop cultivars to increase yield and quality as well tolerance to environmental stresses but our knowledge of regulatory network is still not sufficient to decipher the exact mechanism. In the current work, stress-specific TF-miRNA-gene network was built for Arabidopsis under drought, cold, salt and waterlogging stress using data from reliable publically available databases; and transcriptome and degradome sequence data analysis by meta-analysis approach. Further network analysis elucidated significantly dense, scale-free, small world and hierarchical backbone of interactions. The various centrality measures highlighted several genes/TF/miRNAs as potential targets for tolerant variety cultivation. This comprehensive regulatory information will accelerate the advancement of current understanding on stress specific transcriptional and post-transcriptional regulatory mechanism and has promising utilizations for experimental biologist who are intended to improve plant crop performance under multiple Abiotic stress environments. Copyright © 2019. Published by Elsevier Inc.

Report this publication

Statistics

Seen <100 times