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Effect of four convulsants on the time course of presynaptic inhibition and its relation to seizure activity

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
16
Issue
11
Identifiers
DOI: 10.1016/0028-3908(77)90129-0
Keywords
  • Convulsants
  • Excitability Testing
  • Cuneate Nucleus

Abstract

Abstract The effects of bicuculline, picrotoxin, leptazol and bemegride on presynaptic inhibition were studied in the rat cuneate nucleus, using the excitability testing technique to measure the depolarization of the primary afferent terminals (PAD). Depolarization of primary afferent terminals was represented by the increase in excitability of cuneate presynaptic terminals produced by conditioning volleys from the median nerve (applied 10–70 msec before the test volley). None of the convulsants had any effect on resting terminal excitability, but bicuculline reduced the increase in excitability obtained with conditioning-test intervals of 10–30 msec, and picrotoxin, leptazol and bemegride reduced it over all the intervals tested. The reduction in PAD occurred simultaneously with the first signs of convulsant effects in the electrocorticogram.

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