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Aberrant gray matter volumes and functional connectivity in adolescent patients with ADHD.

Authors
  • Zhao, Yue1, 2
  • Cui, Dong3
  • Lu, Weizhao2, 4
  • Li, Hongyu1
  • Zhang, Huayu1
  • Qiu, Jianfeng2, 4
  • 1 The Shandong University of Science and Technology, Qingdao, China. , (China)
  • 2 Medical Engineering and Technology Research Center, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China. , (China)
  • 3 Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. , (China)
  • 4 Radiology Department, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China. , (China)
Type
Published Article
Journal
Journal of Magnetic Resonance Imaging
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 01, 2020
Volume
51
Issue
3
Pages
719–726
Identifiers
DOI: 10.1002/jmri.26854
PMID: 31265198
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Altered gray matter (GM) volumes and functional connectivity (FC) happens in attention-deficit/hyperactivity disorder (ADHD) patients and the intelligence quotient (IQ) of ADHD patients is generally lower than healthy subjects, while few studies have focused on the association among the three. To investigate the abnormal changes of GM volumes and FC in ADHD patients compared with typically-developing control (TD-C), as well as the association between the changes and IQ. Case control. 36 ADHD patients and 36 TD-C, aged 8-17. 3.0T/single shot echo planar imaging (EPI). Preprocessing of fMRI data and seed-based FC calculation using DPABI4.0, and VBM was performed by CAT12. Comparison between groups of smoothed GM volumes was performed using two-sample t-test within SPM 12, age and total intracranial volume (TIV) were returned as covariates. Comparison between groups of FCs was performed using a two-sample t-test within RESTplus; age was returned as a covariate. False discovery rate (FDR)-corrected and P < 0.05 was considered statistically significant. Compared with TD-C, reduced GM volumes occurred in the left superior frontal gyrus (t = -3.61, P < 0.001), right middle frontal gyrus (t = -3.97, P < 0.001), left middle cingulum (t = -3.93, P < 0.001), and left cuneus (t = -4.42, P < 0.001). Decreased FC was found between the left precuneus and left middle cingulum (t = -5.86, P < 0.001), left middle temporal gyrus, and left superior frontal gyrus (t = -5.67, P < 0.001), as well as left medial superior frontal gyrus and left superior frontal gyrus (t = -6.73, P < 0.001). The results confirmed that FCs between the regions with declined GM volumes and others were altered in ADHD patients. We speculated that abnormal changes of GM volume and FC maybe used as an imaging metric of ADHD. 2 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2020;51:719-726. © 2019 International Society for Magnetic Resonance in Medicine.

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