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Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis

Authors
  • Zhang, Huayu1
  • Zhao, Yue1, 2
  • Cao, Weifang2, 3
  • Cui, Dong2, 3
  • Jiao, Qing2, 3
  • Lu, Weizhao2, 3
  • Li, Hongyu1
  • Qiu, Jianfeng2, 3
  • 1 Shandong University of Science and Technology, No. 579, Qianwan’ gang Road, Qingdao, Shandong, 266590, China , Qingdao (China)
  • 2 Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China , Taian (China)
  • 3 Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, China , Taian (China)
Type
Published Article
Journal
BMC Neuroscience
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Sep 18, 2020
Volume
21
Issue
1
Identifiers
DOI: 10.1186/s12868-020-00589-x
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD.MethodsThe data were obtained from the ADHD-200 Global Competition, including fMRI data from 88 ADHD patients (56 patients of ADHD-Combined, ADHD-C and 32 patients of ADHD-Inattentive, ADHD-I) and 67 typically developing controls (TD-C). Group ICA was utilized to research aberrant brain functional connectivity within the different subtypes of ADHD.ResultsIn comparison with the TD-C group, the ADHD-C group showed clusters of decreased functional connectivity in the left inferior occipital gyrus (p = 0.0041) and right superior occipital gyrus (p = 0.0011) of the dorsal attention network (DAN), supplementary motor area (p = 0.0036) of the executive control network (ECN), left supramarginal gyrus (p = 0.0081) of the salience network (SN), middle temporal gyrus (p = 0.0041), and superior medial frontal gyrus (p = 0.0055) of the default mode network (DMN), while the ADHD-I group showed decreased functional connectivity in the right superior parietal gyrus (p = 0.0017) of the DAN and left middle temporal gyrus (p = 0.0105) of the DMN. In comparison with the ADHD-I group, the ADHD-C group showed decreased functional connectivity in the superior temporal gyrus (p = 0.0062) of the AN, inferior temporal gyrus (p = 0.0016) of the DAN, and the dorsolateral superior frontal gyrus (p = 0.0082) of the DMN. All the clusters surviving at p < 0.05 (AlphaSim correction).ConclusionThe results suggested that decreased functional connectivity within the DMN and DAN was responsible, at least in part, for the symptom of inattention in ADHD-I patients. Similarly, we believed that the impaired functional connectivity within networks may contribute to the manifestations of ADHD-C patients, including inattention, hyperactivity/impulsivity, and unconscious movements.

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