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Abdominal aortic aneurysm as an IgG4-related disease.

Authors
  • Prucha, M1
  • Sedivy, P2
  • Stadler, P2
  • Zdrahal, P2
  • Prokopova, P3
  • Voska, L4
  • Sedlackova, L1
  • 1 Department of Clinical Biochemistry, Haematology and Immunology, Na Homolce Hospital, Prague, Czech Republic. , (Czechia)
  • 2 Department of Vascular Surgery, Na Homolce Hospital, Prague, Czech Republic. , (Czechia)
  • 3 Department of Pathology, Na Homolce Hospital, Prague, Czech Republic. , (Czechia)
  • 4 Department of Clinical and Experimental Pathology, IKEM, Prague, Czech Republic. , (Czechia)
Type
Published Article
Journal
Clinical & Experimental Immunology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2019
Volume
197
Issue
3
Pages
361–365
Identifiers
DOI: 10.1111/cei.13307
PMID: 31032886
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected with fibrotic or sclerotizing changes and typical histopathological features. It was identified as a possible cause of vasculitis in large vessels. Studies have been published on a possible association between inflammatory aortic or cardiovascular disease and IgG4-RD. We examined 114 patients with AAA requiring surgery in order to identify findings which are characteristic of IgG4-RD. Aneurysm samples from seven patients showed histopathological features consistent with IgG4-RD and the presence of IgG4+ plasma cells. Only two of these seven patients showed elevated IgG4 serum levels higher 1·35 g/l. In five of the patients, the concentration of serum IgG4 was lower than 1·20 g/l, with the number of IgG4+ plasma cells being higher than 50/high-power field. These findings were consistent with AAA being a heterogeneous group of inflammatory diseases with different pathogenesis. © 2019 The Authors. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology.

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