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Pseudoarylsulfatase A Deficiency in a Psychiatrically Disturbed Adolescent

Authors
Journal
Journal of the American Academy of Child & Adolescent Psychiatry
0890-8567
Publisher
Elsevier
Publication Date
Volume
28
Issue
3
Identifiers
DOI: 10.1097/00004583-198905000-00025
Keywords
  • Organic Brain Syndrome
  • Pseudoarylsulfatase A Deficiency
  • Adolescence
Disciplines
  • Medicine

Abstract

Abstract A case of pseudoarylsulfatase A deficiency in an adolescent boy presenting with affective lability, impulsivity, aggression, inattention, and academic difficulties is described. Genetically related to metachromatic leukodystrophy, pseudoarylsulfatase A deficiency has generally been felt to be a benign disorder. Pseudodeficiency of arylsulfatase A has, however, been associated with serious psychiatric morbidity in recent studies. Possible explanations for this association are suggested. To the best of the authors' knowledge, this is the first case report of pseudoarylsulfatase A deficiency in a psychiatrically disturbed adolescent.

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