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The coffee diterpene kahweol inhibits metastasis by modulating expressions of MMPs and VEGF via STAT3 inactivation

Authors
Journal
Food Chemistry
0308-8146
Publisher
Elsevier
Publication Date
Volume
133
Issue
4
Identifiers
DOI: 10.1016/j.foodchem.2012.02.043
Keywords
  • Kahweol
  • Stat3
  • Vegf
  • Metastasis
  • Mmps
Disciplines
  • Biology

Abstract

Abstract Kahweol, a coffee-specific diterpene, is reported to have anti-cancer properties, although its precise chemopreventive mechanism remains unclear. The aim of our study was to determine the effect of kahweol on anti-metastatic activities and the possible mechanisms. Kahweol inhibited the migration and invasion ability of various cancer cells in vitro and decreased the secretion of metalloproteinase (MMP)-2, MMP-9, and VEGF in cancer cells via suppression of STAT3 activation. Kahweol also exhibited an inhibitory effect on lung metastasis in the experimental B16-F10 melanoma metastasis model. Moreover, kahweol inhibited migration and tube formation of endothelial cells in vitro, decreased the secretion of VEGF, and suppressed neovascularisation in Matrigel plugs in mice. Our findings demonstrate that kahweol inhibits metastasis through the disruption of STAT3-mediated transcription of the MMP and VEGF genes.

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