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Evidence of 2-hydroxylation of estradiol-17β 17-glucuronide by male rat liver microsomes

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
42
Issue
2
Identifiers
DOI: 10.1016/s0039-128x(83)90184-8

Abstract

Abstract When estradiol-17β 17-glucuronide was incubated with male rat liver microsomal preparations with a NADPH-generating system, 2-hydroxyestradiol -17β 17-glucuronide was obtained. This 2-hydroxylation was shown to occur without cleavage of the conjugate group. The result clearly indicates that estradiol-17β 17-glucuronide could act as substrate for rat liver microsomal 2-hydroxylase.

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