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Phosphoregulation of CdGAP and DCC, proteins involved in actin dynamics

McGill University
Publication Date
  • Biology
  • Molecular.
  • Biology


The Rho GTPases are members of the Ras superfamily of small monomeric GTP binding proteins that regulate multiple cellular processes affecting both cell proliferation and cytoskeletal dynamics. They are positively and negatively regulated by the guanine nucleotide exchange factors (GEFs) and the GTPase-activating proteins (GAPS), respectively. In principle, extracellular signals such as growth factors and other agents bind to plasma membrane receptors and modulate Rho GTPase function through intracellular mechanisms that affect GEF or GAP activities. There is now compelling evidence that both receptors and cytoplasmic proteins implicated in Rho GTPase signaling are modulated by post-translational modifications such as phosphorylation.

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