Affordable Access

Publisher Website

Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
486
Issue
3
Identifiers
DOI: 10.1016/j.neulet.2010.09.063
Keywords
  • White Matter Lesions
  • Blood–Brain Barrier
  • Tight Junction Proteins
  • Claudin-5
  • Occludin
  • Zo-1
Disciplines
  • Biology

Abstract

Abstract White matter lesions (WML) are associated with dementia and are common in brain ageing. In order to determine whether alteration of the blood–brain barrier (BBB) may contribute to the pathogenesis of WML we assessed albumin leakage and expression of the tight junction (TJ) proteins claudin-5 (Cln-5), zona occludin-1 (ZO-1) and occludin in cases derived from the Medical Research Council Cognitive Function and Ageing Study. Albumin extravasation was widespread in the ageing brain and enhanced in WML, suggesting dysfunction of the BBB may contribute to the pathogenesis of WML. This was not accompanied by significant changes in the endothelial expression of TJ proteins. However, ZO-1 and occludin were expressed by glial cells throughout the parenchyma of both control white matter and WML, suggesting these TJ proteins may have other functions in the brain.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Alterations of the blood-brain barrier and glial c...

on Stroke; a journal of cerebral... November 1996

Alterations of the blood-brain barrier and glial c...

on Stroke; a journal of cerebral... April 1997

Cerebral white matter changes in acquired immunode...

on Annals of Neurology September 1993

Blood-brain barrier disruption in white matter les...

on Journal of cerebral blood flow... January 2002
More articles like this..