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Excess melanocytic nevi in children with renal allografts

Authors
Journal
Journal of the American Academy of Dermatology
0190-9622
Publisher
Elsevier
Publication Date
Volume
28
Issue
1
Identifiers
DOI: 10.1016/0190-9622(93)70008-h
Disciplines
  • Medicine

Abstract

Background: Renal allograft transplantation is associated with an increased incidence of malignant melanoma. The development of excess melanocytic nevi may be an indicator of this risk. Objective: This study determines the prevalence of melanocytic nevi in children who have received renal allografts. Methods: Total and regional melanocytic nevi counts were made in 38 children (27 boys, 11 girls) with a renal allograft and in 38 individually age- and sex-matched healthy controls; counts were related to age, sex, skin type, and duration of immunosuppression. Results: There was a significant increase in the total number of nevi in the renal transplant group compared with the control group ( p < 0.05), with most marked increases occurring on the back and at acral sites. A strong positive correlation between nevi count and duration of immunosuppression independent of age was observed ( p < 0.005). Conclusion: Excess numbers of melanoeytic nevi occur in children with renal allografts. These patients constitute a risk group for malignant melanoma and require continued assessment.

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