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Suppression of aminoacyladenylate synthesis by methyl mercury in vitro and in vivo

Authors
Journal
Toxicology Letters
0378-4274
Publisher
Elsevier
Publication Date
Volume
36
Issue
2
Identifiers
DOI: 10.1016/0378-4274(87)90180-9
Keywords
  • Methyl Mercury
  • Aminoacyladenylates
  • Ph 5 Enzymes

Abstract

Abstract Methyl mercury (MeHg) at a concentration of 20 μM significantly inhibits the synthesis of aminoacyladenylates (AAA) in vitro from serine and histidine, and fails to inhibit AAA synthesis from phenylalanine, leucine, arginine and aspartate. In vivo administration of MeHg (single i.p. injection of 50 nmol/g body weight) leads to 75–80% suppression of AAA synthesis from serine, histidine, phenylalanine, leucine, arginine and aspartate in rat brain tissue.

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