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Transcript quantification of Dresden G protein-coupled receptor (D-GPCR) in primary prostate cancer tissue pairs

Authors
Journal
Cancer Letters
0304-3835
Publisher
Elsevier
Publication Date
Volume
236
Issue
1
Identifiers
DOI: 10.1016/j.canlet.2005.05.005
Keywords
  • Expression Profile
  • G Protein-Coupled Receptor
  • Lightcycler
  • Prostate Cancer
  • Quantitative Real-Time Pcr
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Recently, we identified the novel protein D-GPCR (Dresden G protein-coupled receptor) which is selectively overexpressed in human prostate cancer (PCa) and belongs to the subfamily of odorant-like orphan GPCRs. Quantification of D-GPCR transcripts in paired malignant and non-malignant prostate tissues of 106 patients with primary PCa by real-time PCR demonstrated a significant up-regulation of this gene in tumor samples. Furthermore, its expression increases with higher tumor stages and grades. The evaluation of D-GPCR expression as a potential molecular tumor marker was performed by receiver-operating characteristic curve (ROC) analysis resulting in an area under the curve (AUC) value of 0.6452. Hence, the evaluation of D-GPCR as possible additive diagnostic tool and putative therapy target appears promising.

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