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Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

Authors
Journal
Current Opinion in Cell Biology
0955-0674
Publisher
Elsevier
Publication Date
Volume
7
Issue
6
Identifiers
DOI: 10.1016/0955-0674(95)80063-8
Disciplines
  • Biology

Abstract

Abstract Evolutionarily conserved from yeast to man, mitogen-activated protein kinase (MAPK) pathways respond to a variety of disparate signals which induce differentiation, proliferation, or changes in intracellular enzyme regulation. Recent advances have identified two new mammalian MAPK relatives, JNK1 and p38, and the pathways which are responsible for their activation.

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