Affordable Access

Publisher Website

Sterol-mycobacillin interaction in a monolayer

Authors
Journal
Chemistry and Physics of Lipids
0009-3084
Publisher
Elsevier
Publication Date
Volume
23
Issue
1
Identifiers
DOI: 10.1016/0009-3084(79)90026-4

Abstract

Abstract The isotherms, π-A curves at air-water interface for mycobacillin, cholesterol, ergosterol, ergocalciferol, stigmasterol and cholesterol benzoate show that the antibiotic is compressible and collapses at 11.5 dyn/cm whereas the sterols are generally incompressible and do not show collapse within the limits of our experiments. The isotherms of a binary mixture of mycobacillin with any one of the sterols in several molar proportions showed marked condensation with cholesterol, complete absence of condensation with cholesterol benzoate and feeble condensation with the rest of sterols. The implications of these findings are discussed in favour of sterol-mycobacillin interaction to account for reversal of mycobacillin inhibition by sterols.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Monolayer interactions of individual lecithins wit...

on Biochimica et Biophysica Acta Apr 14, 1972

The impact of sterol structure on the interactions...

on The Journal of Physical Chemis... Sep 11, 2008

Monolayer interactions of individual lecithins wit...

on Biochimica et Biophysica Acta... Jan 01, 1972

Effect of sterol side-chain structure on sterol-ph...

on Biochimica et Biophysica Acta Mar 23, 1994
More articles like this..