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Structure of microarc oxidized coatings containing Si, Ca and Na on titanium and deposition of cefazolin sodium/chitosan composite film

Authors
Journal
Surface and Coatings Technology
0257-8972
Publisher
Elsevier
Publication Date
Volume
205
Identifiers
DOI: 10.1016/j.surfcoat.2011.01.042
Keywords
  • Microarc Oxidation
  • Titanium
  • Titania
  • Cefazolin Sodium
  • Chitosan
  • Bioactive Glass Components
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract Microarc oxidized (MAO) coatings containing Si, Ca and Na elements (SCN) were prepared on titanium. The morphology, phase composition and elemental concentrations of the MAO coating surfaces highly depended on the applied voltages. The MAO coatings containing SCN show an atomic concentration gradient along the coating depth. The chemical states of Ti2+, Ti4+, Ca2+, Si2+ and O2− were observed in all the MAO coatings. The novel cefazolin sodium/chitosan composite films were deposited on the MAO coatings for application in therapy of the inflammation resulting from implanting. The increases of depositing times and cefazolin sodium concentration could increase the accumulative release concentration of cefazolin sodium, and could improve the sustaining-release ability of drug film. Also, the addition of chitosan could improve the sustaining-release ability of drug film, indicated that chitosan is a promising delivery carrier for cefazolin sodium.

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