Abstract The prevalence of mitral valve prolapse (MVP) reportedly ranges from 4 to 17% in women and 2 to 4% in men. 1 It declines with increasing age in women, but remains unchanged in men. 1 The prevalence of MVP may also be influenced by the clinical and echocardiographic criteria used for diagnosis. 1 MVP usually occurs as a primary disorder and is commonly, but not invariably, associated with myxomatous proliferation of the mitral valve and chordae tendineae. 2 Numerous diseases have been reported to predispose to MVP, but cumulalively account for <5% of all cases. 2 Low body weight is frequently observed in patients with primary MVP and in some secondary disorders associated with MVP (e.g., anorexia nervosa.). 3 Its prevalence in obese persons is uncertain. This study assesses the prevalence of MVP in patients with extreme (morbid) obesity.