Affordable Access

Publisher Website

The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients

Authors
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
0278-5846
Publisher
Elsevier
Publication Date
Volume
43
Identifiers
DOI: 10.1016/j.pnpbp.2013.01.003
Keywords
  • Gene Expression
  • Hif-1
  • Leukocyte
  • Mood Disorder
  • Vegf
Disciplines
  • Biology

Abstract

Abstract Recent studies suggest that the dysfunction of neural plasticity is associated with mood disorders. Hypoxia-inducible factor-1 (HIF-1), which is a transcriptional activator of vascular endothelial growth factor (VEGF), activates the cellular response to hypoxia. HIF-1 is ubiquitously expressed in all cells, including peripheral leukocytes. However, little is known about the role of HIF-1 in mood disorder. In the present study, we investigated the mRNA expression levels of HIF-1 (α and β) and its target genes (VEGF, GLUT1, PGK1, PFKFB3, and LDHA) in the peripheral white blood cells of patients with major depressive disorder (MDD) and bipolar disorder (BPD). We found increased expression of HIF- 1α and HIF-1β mRNA, as well as the target genes, VEGF, and PFKFB3 in both MDD and BPD patients in a depressive state compared to healthy control subjects. Furthermore, the mRNA expression levels of GLUT1, PGK1, and LDHA were increased in MDD patients in a depressive state compared to healthy control subjects. We also found increased expression of HIF-1α and LDHA mRNA in MDD patients in a remissive state, whereas the mRNA expression levels of other genes in a remissive state were comparable to those in healthy control subjects. There was no significant difference in mRNA expression levels of the genes examined among patients receiving any type of antidepressant or mood stabilizer. Our data suggest that altered expression of HIF-1 and its target genes mRNA in peripheral blood cells are associated—mainly in a state-dependent manner—with mood disorders (especially with MDD). In addition, altered expression of HIF-1 and its target genes may be associated with the pathophysiology of depression.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Hypoxia inducible factor-1α (HIF-1α) and some HIF-...

on Journal of molecular neuroscie... October 2010

Induction of hypoxia-inducible factor-1 (HIF-1) an...

on The European journal of neuros... December 1999

Upstream stimulatory factor 2 and hypoxia-inducibl...

on Molecular and Cellular Biology November 2012
More articles like this..