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Green oxidation of alcohols using biomimetic Cu complexes and Cu enzymes as catalysts

Elsevier Science & Technology
DOI: 10.1016/s0898-8838(05)58006-1
  • Biology
  • Chemistry
  • Design


Publisher Summary This chapter discusses green oxidation of alcohols using biomimetic Cu complexes and Cu enzymes as catalysts. The oxidation of alcohols to carbonyl compounds is one of the most fundamental and important processes in the fine chemical industry. The classical methodology is based on the stoichiometric use of heavy metals, notably Cr and Mn. The desired oxidation of alcohols only requires the formal transfer of two hydrogen atoms, and therefore the atom economy of these methods is extremely disadvantageous. The current state of the art in alcohol oxidations relies on the use of chemocatalysts employing molecular oxygen or dihydrogen peroxide as the final oxidant. These copper-containing oxidases provide a wealth of inspiration to the design of efficient copper-catalysts. The chapter also provides the examples of biomimetic and biocatalytic copper-based redox-catalysts that could be used for the green and selective oxidation of alcohols. Copper-containing oxidases can be divided into enzymes with mononuclear copper-sites, dinuclear copper-sites, and enzymes with multinuclear copper sites.

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