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Design of a new formulation for sustained release of gentamicin: A Carbopol hydrogel

Authors
Journal
International Journal of Pharmaceutics
0378-5173
Publisher
Elsevier
Publication Date
Volume
133
Identifiers
DOI: 10.1016/0378-5173(95)04413-2
Keywords
  • Gentamicin
  • Carbopol
  • Polymer
  • Delivery Systems
  • Sustained Release

Abstract

Abstract Two gentamicin-containing hydrogels of different water solubility have been prepared using Carbopol as a thickening agent. The most insoluble hydrogel (A) released its drug content extremely slowly, regardless of the absence or presence of plasma. In contrast, the rate of drug release from hydrogel B was just slightly slower than the free drug in saline, whereas in the presence of plasma components just 35% of the gentamicin contained in hydrogel B was eventually released from it. Pharmacokinetic studies showed a sustained release of gentamicin from the Carbopol hydrogel (B), with an elimination half-life in excess of 2.5 h.

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