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Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity

Authors
Journal
European Journal of Medicinal Chemistry
0223-5234
Publisher
Elsevier
Publication Date
Volume
48
Identifiers
DOI: 10.1016/j.ejmech.2011.11.036
Keywords
  • 2
  • 5-Dihydrofuran Derivatives
  • Metal-Catalyzed Cycloaddition Reaction
  • Synthesis
  • Crystal Structure
  • Anti-Cancer Activity
Disciplines
  • Design

Abstract

Abstract According to metal-catalyzed [3 + 2] cycloaddition reaction, we synthesized a series of novel 2, 5-dihydrofuran derivatives and evaluated their in vitro anti-cancer activities via MTT method. The bioassay showed that the majority of the resultant compounds exerted anti-tumor effect against four human cancer cell lines to various extents, which supported the rationale of the design. Compounds 9e and 10g showed the highest activity with broad anti-cancer spectrum, which were good candidates for further evaluation.

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