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Malignant schwannoma of the upper mediastinum originating from the vagus nerve

Authors
Publisher
BioMed Central
Publication Date
Source
PMC
Keywords
  • Case Report
Disciplines
  • Medicine

Abstract

1477-7819-3-65.fm ral World Journal of Surgical Oncology ss BioMed Cent Open AcceCase report Malignant schwannoma of the upper mediastinum originating from the vagus nerve Fumihiro Shoji*1, Riichiroh Maruyama1, Tatsuro Okamoto1, Hiroshi Wataya1, Kenichi Nishiyama2 and Yukito Ichinose1 Address: 1Department of Thoracic Oncology, Kyushu Cancer Center, 3-1-1, Notame, Minami-ku, Fukuoka 811-1395, Japan and 2Department of Pathology, Kyushu Cancer Center, 3-1-1, Notame, Minami-ku, Fukuoka 811-1395, Japan Email: Fumihiro Shoji* - [email protected]; Riichiroh Maruyama - [email protected]; Tatsuro Okamoto - [email protected]; Hiroshi Wataya - [email protected]; Kenichi Nishiyama - [email protected]; Yukito Ichinose - [email protected] * Corresponding author Abstract Background: Malignant schwannoma of the upper mediastinum originating from the vagus nerve is extremely rare. Case presentation: A 46-year-old female was admitted for a left cervical mass which was associated with both hoarseness and Horner's syndrome. Chest computed tomography showed a mass extending from the left upper mediastinum to the left supraclavicular area. A fine needle aspiration cytological examination suggested primary lung cancer stage IIIB large cell carcinoma. After administering induction chemo-radiotherapy, a complete surgical resection was performed. The tumor was found to involve both the left vagus nerve and the left sympathetic nerve. Histological examination of the resected specimen revealed the tumor to be malignant schwannoma. Conclusion: Despite incorrect preoperative diagnosis, the multimodality treatment administered in this case, including induction chemo-radiotherapy and surgery, proved to be effective. Background According to a collected series of 2399 cases of mediasti- nal tumors reported in the literature [1], 496 cases (20.7%) were of neurogenic tumors, and most of them occurred in the posterior mediastinum. Neurogenic tumors can be divided into two groups de

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