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Ductal carcinoma in situ (DCIS): are we overdetecting it?

Breast Cancer Research
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/bcr842
  • Oral Presentation
  • Biology
  • Medicine
  • Pharmacology


S1 Available online Abstracts from Symposium Mammographicum 2004 Edinburgh International Conference Centre, 19–20 July 2004 1 Developing new treatments for breast cancer D Lane University of Dundee, UK and Cyclacel Ltd, UK Breast Cancer Res 2004, 6(Suppl 1):P1 (DOI 10.1186/bcr820) Twenty-five years after its first description the p53 protein has been shown to play a key role in both cancer and ageing. The p53 protein is activated by many different stress pathways, including oncogene action and DNA damage. The elucidation of the p53 response, which is aberrant in most cancers (including breast, lung, stomach and colorectal cancer), has provided many new targets for drug development and p53 gene therapy is now approved in China. In tumours where p53 is mutant small molecules may be able to restore its function. In many tumours the wild-type p53 gene remains intact but its function is compromised by loss of upstream signalling pathways or downstream effectors. A key regulator is Mdm2, an E3 ubiquitin ligase, that binds and ubiquitinates p53 and directs its degradation via the proteosome. Small potent peptides that can block the p53 Mdm2 interaction and activate the p53 response have been described. Growing selections of lead small molecules that mimic the action of these peptides have also been recently discovered. Cell-based screens have revealed that inhibitors of nuclear export and inhibitors of transcription (one of which is in clinical trial) can also activate the p53 response therapeutically. The pharmaceutical regulation of the p53 pathway offers great hope for improved treatment of human cancer. 2 Mammographic screening with a breast cancer prevention programme P Boyle Director, International Agency for Research on Cancer, Lyon, France Breast Cancer Res 2004, 6(Suppl 1):P2 (DOI 10.1186/bcr821) 3 Sonographic evaluation of solid breast nodules T Stavros University of Colorado, Denver, USA Breast Cancer Res 2004, 6(Suppl 1)

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