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Effects of postsynaptic depolarization in the induction of synaptic depression between a granule cell and a Purkinje cell in rat cerebellar culture

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
119
Issue
2
Identifiers
DOI: 10.1016/0304-3940(90)90819-u
Keywords
  • Synaptic Plasticity
  • Long-Term Depression
  • Postsynaptic Depolarization
  • Motor Learning
  • Cerebellum
  • Granule Cell
  • Purkinje Cell
  • Culture

Abstract

Abstract In a previous paper it has been reported that the repetitive conjunctive stimulation of both a granule cell and an inferior-olivary neuron depresses the synaptic transmission between a cerebellar granule cell and a Purkinje cell, and the repetitive stimulation of only a granule cell potentiates the transmission in a simple culture preparation. This paper demonstrates, by experiments controlling the membrane potential of a postsynaptic Purkinje cell, that the postsynaptic depolarization of a Purkinje cell during activation of a granule cell is both necessary and sufficient to induce the depression, and that the potentiation is induced without the postsynaptic depolarization.

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