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Combinatorial biosynthesis<query id="Q1">No queries.</query>for drug development

Authors
Journal
Current Opinion in Microbiology
1369-5274
Publisher
Elsevier
Publication Date
Volume
10
Issue
3
Identifiers
DOI: 10.1016/j.mib.2007.05.005
Disciplines
  • Biology
  • Chemistry
  • Engineering
  • Mathematics
  • Medicine

Abstract

Combinatorial biosynthesis can refer to any strategy for the genetic engineering of natural product biosynthesis to obtain new molecules, including the use of genetics for medicinal chemistry. However, it also implies the possibility that large libraries of complex compounds might be produced to feed a modern high-throughput screening operation. This review focuses on the multi-modular enzymes that produce polyketides, nonribosomal peptides, and hybrid polyketide-peptide compounds, which are the enzymes that appear to be most amenable to truly combinatorial approaches. The recent establishment of a high-throughput strategy for testing the activity of many non-natural combinations of modules from these enzymes should help speed the advance of this technology.

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