Affordable Access

Publisher Website

Recent insights into non-nuclear actions of estrogen receptor alpha

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Volume
81
Identifiers
DOI: 10.1016/j.steroids.2013.11.002
Keywords
  • Bone Mineralization
  • Caveolae
  • Endothelium
  • Estrogen Receptor
  • Nitric Oxide Synthase
  • Vascular Smooth Muscle
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Estrogen receptors (ER) classically function as transcription factors regulating gene expression. More recently, evidence has continued to accumulate that ER additionally serve numerous important functions remote from the nucleus in a variety of cell types, particularly in non-reproductive tissues. The identification of post-translational modifications of ERα and protein–protein interactions with the receptor that are critical to its non-nuclear functions has afforded opportunities to gain greater insights into these novel non-genomic roles of the receptor. The development of a stable ligand that selectively activates non-nuclear ER has also been invaluable. In this review focused on ERα, recent new understanding of the processes underlying non-nuclear ER action and their in vivo consequences will be discussed. Further research into the non-nuclear capacities by which ER modulate cellular behavior is essential to ultimately harnessing these processes for therapeutic gain in numerous disease contexts.

There are no comments yet on this publication. Be the first to share your thoughts.