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Cardiovascular effects of statins, beyond lipid-lowering properties

Authors
Journal
Pharmacological Research
1043-6618
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.phrs.2014.02.009
Keywords
  • 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors
  • Cardiovascular Disorders
  • Pleiotropic Effects
  • Statins
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, better known as ‘statins’, are amongst the most widely used medications in the world. They have become a pivotal component in the primary and secondary prevention of coronary artery and vascular disease. However, a growing amount of evidence has suggested that statins also possess strong pleiotropic effects irrespective of their lipid-lowering properties, which include enhancement of endothelial function, anti-inflammatory and anti-atherothrombotic properties, and immunomodulation. The following provides a comprehensive and updated review of the clinical evidence regarding the pleiotropic effects of statins in cardiovascular disorders and their potential therapeutic benefits.

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