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Is there Kveim responsiveness in Crohn's disease?

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
298
Issue
7725
Identifiers
DOI: 10.1016/s0140-6736(71)80072-7
Disciplines
  • Medicine

Abstract

Summary No microscopically positive Kveim reactions were observed among 23 patients with Crohn's disease. The Kveim-test suspensions employed in this study, spleen J and K 12, were potent and specific as judged by the high proportion of positive Kveim reactions (83–87%) concurrently evoked by the suspensions in 30 patients with sarcoidosis and by the negative Kveim reactions among 15 patients with non-granulomatous disorders. These uniformly negative results are not in accord with recent reports of frequent positive Kveim reactions in patients with Crohn's disease. Closer scrutiny of the specificity of various lots of Kveim-test suspensions now in use may be required to explain the discordant results of Kveim testing in patients with Crohn's disease.

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