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Effect of estrogen and progesterone on the hepatic cholesterol 7α-hydroxylase activity in ovariectomized baboons

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
0005-2760
Publisher
Elsevier
Publication Date
Volume
1084
Issue
3
Identifiers
DOI: 10.1016/0005-2760(91)90072-p
Keywords
  • Cholesterol
  • Bile Acid
  • Estrogen
  • Progesterone
  • Hormone

Abstract

Abstract Cholesterol 7α-hydroxylase activity was measured in livers from ovaeriectomized baboons fed a high cholesterol high saturated fat diet and maintained in four groups: untreated control, estrogen (100 μg/g per week), progesterone (3 mg/kg per day) and estrogen + progesterone. Estrogen treatment alone increased hepatic 7α-hydroxylase activity by 2.7-fold, whereas progesterone treatment alone did not influence hepatic 7α-hydroxylase activity. The increase in 7α-hydroxylase activity in estrogen + progesterone group was similar to that in the estrogen group.

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