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Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model11This work represents the opinion of the authors, and does not reflect the official policy or position of the United States Air Force, or the Department of Defense.

Authors
Journal
The American Journal of Surgery
0002-9610
Publisher
Elsevier
Volume
178
Issue
6
Identifiers
DOI: 10.1016/s0002-9610(99)00238-x
Disciplines
  • Biology

Abstract

Abstract Background: The selectin glycoproteins are involved in the pathogenesis of renal ischemia-reperfusion injury. We investigated the ability of glycyrrhizin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion injury. Methods: Eighteen New Zealand white rabbits underwent midline laparotomy with renal artery cross-clamping. After 30 minutes of reperfusion, group 1 (control, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared between the two groups after 72 hours of reperfusion. A t test was utilized, with α set at P <0.05. Results: Group 1 and group 2 animals had similar baseline renal function. However, after 72 hours of reperfusion, group 1 animals had a significantly higher mean blood urea nitrogen creatinine ratio than group 2 animals (P <0.01), indicating preserved renal function in rabbits treated with glycyrrhizin. Conclusions: Selectin blockade using glycyrrhizin attenuates renal ischemia-reperfusion injury when given 30 minutes after the onset of reperfusion in a rabbit model.

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