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A83586C, a new depsipeptide antibiotic.

Authors
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Volume
41
Issue
6
Pages
726–733
Identifiers
PMID: 3403366
Source
Medline

Abstract

A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C. A83586C had potent Gram-positive activity in vitro but lacked in vivo efficacy in mice.

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