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Adenosine enhanced preconditioning prevents apoptosis in the small intestine and inhibits bacterial translocation

Critical Care
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/cc1934
  • Meeting Abstract
  • Medicine


S1 Available online Critical Care Volume 7 Suppl 2, 2003 23rd International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium, 18–21 March 2003 Published online: 3 March 2003 This article is online at © 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) P1 Endocrine dysfunction in the immediate period following traumatic brain injury I Dimopoulou, S Tsagarakis, G Assithianakis, M Christoforaki, M Theodorakopoulou, A Kouyialis, S Korfias, N Thalassinos, C Roussos Department of Critical Care Medicine and Department of Endocrinology, Evangelismos Hospital, Athens, Greece Critical Care 2003, 7(Suppl 2):P001 (DOI 10.1186/cc1890) Studies on head injury-induced pituitary dysfunction are limited in number and conflicting results have been reported. To further clarify this issue, 29 consecutive patients (24 males), with severe (n=21) or moderate (n=8) head trauma, having a mean age of 37±17 years were investigated in the immediate post-trauma period. All patients required mechanical ventilatory support for 8–55 days and were enrolled in the study within a few days before ICU discharge. Basal hormonal assessment included measurement of cortisol, corticotropin, free thyroxine (fT4), thyrotropin (TSH), testosterone (T) in men, estradiol (E2) in women, prolactin (PRL), and growth hormone (GH). Cortisol and GH levels were measured also after stimulation with 100µg human corticotropin releasing hormone (hCRH) and 100µg growth hormone releasing hormone (GHRH), respectively. Cortisol hyporesponsiveness was consid- ered when peak cortisol concentration was less than 20µg/dl fol- lowing hCRH. TSH deficiency was diagnosed when a subnormal serum fT4 level was associated with a normal or low TSH. Hypogo- nadism was considered when T (males) or E2 (women) were below the local reference ranges, in the presence of normal PRL levels. Severe or partial GH deficiencies were defined as a peak GH below

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