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Regulation of histone synthesis and nucleosome assembly

Authors
Journal
Biochimie
0300-9084
Publisher
Elsevier
Publication Date
Volume
87
Issue
7
Identifiers
DOI: 10.1016/j.biochi.2005.02.008
Keywords
  • Histone Synthesis
  • Nucleosome Assembly
  • Cell Cycle
  • Chromatin

Abstract

Abstract Histone deposition onto nascent DNA is the first step in the process of chromatin assembly during DNA replication. The process of nucleosome assembly represents a daunting task for S-phase cells, partly because cells need to rapidly package nascent DNA into nucleosomes while avoiding the generation of excess histones. Consequently, cells have evolved a number of nucleosome assembly factors and regulatory mechanisms that collectively function to coordinate the rates of histone and DNA synthesis during both normal cell cycle progression and in response to conditions that interfere with DNA replication.

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